Research workbench
QTRT2, the non-catalytic subunit of murine tRNA-guanine transglycosylase
Analyse QTRT2, the non-catalytic subunit of murine tRNA-guanine transglycosylase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FV5
- Type
- protein
- Length
- 759 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Queuine tRNA-ribosyltransferase accessory subunit 2
- UniProt
- B8ZXI1
- Ligands
- ZN
- Pockets
- 10 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Queuine tRNA-ribosyltransferase accessory subunit 2 | protein | 377 | 40% helix, 18% strand | B8ZXI1 |
| B | Queuine tRNA-ribosyltransferase accessory subunit 2 | protein | 382 | 41% helix, 19% strand | B8ZXI1 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · chains A
- MLI · Malonate ion · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 276 | 0.62 | 0.80 | 42 | empty |
| 2 | 259 | 0.59 | 0.79 | 42 | empty |
| 3 | 109 | 0.47 | 0.79 | 20 | empty |
| 4 | 88 | 0.38 | 0.76 | 19 | empty |
| 5 | 50 | 0.38 | 0.81 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1761 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6FV5 · QTRT2, the non-catalytic subunit of murine tRNA-Guanine Transglycosylase · the same entry in another collection · chain A against A, TM-score 1.00
- B8ZXI1 · AlphaFold monomer V2.0 prediction for queuine tRNA-ribosyltransferase accessory subunit 2… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B8ZXI1
- Elsewhere: RCSB PDB 6FV5 · PDBe 6FV5 · UniProt B8ZXI1
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