Research workbench
Class 2 : distorted nucleosome
Analyse Class 2 : distorted nucleosome in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FQ6
- Type
- protein + DNA
- Length
- 1,046 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3; Histone H4; Histone H2A; Histone H2B; DNA (147-mer)
- UniProt
- P62799, Q6AZJ8, A0A1L8FQ56
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 8 distinct chains · 67% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Histone H3 | protein | 96 | 68% helix, 4% strand | — |
| B | Histone H4 | protein | 83 | 63% helix, 7% strand | P62799 |
| C, G | Histone H2A | protein | 108 | 55% helix, 5% strand | Q6AZJ8 |
| D | Histone H2B | protein | 90 | 77% helix, 3% strand | A0A1L8FQ56 |
| F | Histone H4 | protein | 82 | 62% helix, 7% strand | P62799 |
| H | Histone H2B | protein | 89 | 79% helix, 4% strand | A0A1L8FQ56 |
| I | DNA (147-mer) | dna | 147 | — | — |
| J | DNA (147-mer) | dna | 147 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 623 | 0.78 | 0.84 | 66 | empty |
| 2 | 331 | 0.76 | 0.87 | 52 | empty |
| 3 | 421 | 0.73 | 0.84 | 51 | empty |
| 4 | 328 | 0.71 | 0.84 | 36 | empty |
| 5 | 58 | 0.68 | 0.95 | 23 | empty |
Interfaces
36 interfaces between chains.
- I–J · 6762 Ų buried · 724 hydrogen bonds · nucleic-nucleic
- G–H · 2575 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 2535 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 2407 Ų buried · 18 hydrogen bonds · protein-protein
- E–F · 2391 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 6FQ6 · Class 2 : distorted nucleosome · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62799
- Every structure of UniProt Q6AZJ8
- Every structure of UniProt A0A1L8FQ56
- Elsewhere: RCSB PDB 6FQ6 · PDBe 6FQ6 · UniProt P62799 · UniProt Q6AZJ8 · UniProt A0A1L8FQ56
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