Research workbench
Crystal structure of the human TRIM25 coiled-coil and pryspry domains
Analyse Crystal structure of the human TRIM25 coiled-coil and pryspry domains in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FLN
- Type
- protein
- Length
- 1,097 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 UBIQUITIN/ISG15 ligase TRIM25
- EC
- 6.3.2.-, 2.3.2.27
- UniProt
- Q14258
- Pockets
- 4 · best druggability 0.50
Structure
x-ray diffraction · 3 distinct chains · 45% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 UBIQUITIN/ISG15 ligase TRIM25 (EC 6.3.2.-, 2.3.2.27) | protein | 366 | 45% helix, 22% strand | Q14258 |
| B | E3 UBIQUITIN/ISG15 ligase TRIM25 (EC 6.3.2.-, 2.3.2.27) | protein | 367 | 45% helix, 22% strand | Q14258 |
| E | E3 UBIQUITIN/ISG15 ligase TRIM25 (EC 6.3.2.-, 2.3.2.27) | protein | 364 | 45% helix, 22% strand | Q14258 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 199 | 0.50 | 0.76 | 31 | empty |
| 2 | 198 | 0.49 | 0.76 | 31 | empty |
| 3 | 73 | 0.30 | 0.73 | 16 | empty |
| 4 | 54 | 0.27 | 0.73 | 11 | empty |
Interfaces
2 interfaces between chains.
- A–B · 6799 Ų buried · 50 hydrogen bonds · protein-protein
- A–E · 11 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6FLN · Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains · the same entry in another collection · chain A against A, TM-score 1.00
- Q14258 · AlphaFold monomer V2.0 prediction for E3 UBIQUITIN/ISG15 ligase TRIM25 (Q14258) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14258
- Elsewhere: RCSB PDB 6FLN · PDBe 6FLN · UniProt Q14258
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