UniProt Q14258
E3 ubiquitin/ISG15 ligase TRIM25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (UniProt Q14258), EC 2.3.2.27, 6.3.2.-: 12 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q14258
- Protein
- E3 ubiquitin/ISG15 ligase TRIM25
- EC
- 2.3.2.27, 6.3.2.-
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 21 · 2 records with a druggable one
Structures
13 records of Q14258 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4CFG | Structure of the TRIM25 coiled-coil | x-ray diffraction | A, B | — | — |
| 4CFG | Structure of the TRIM25 coiled-coil | x-ray diffraction | A, B | — | — |
| 5FER | Complex of TRIM25 RING with UbcH5-Ub | x-ray diffraction | A, D | ZN | — |
| 5FER | Complex of TRIM25 ring with UBCH5-ub | x-ray diffraction | A, D | — | — |
| 5NT1 | Complex of influenza A NS1 effector domain with TRIM25 coiled coil | x-ray diffraction | A, E, I | — | — |
| 5NT1 | Complex of influenza a NS1 effector domain with TRIM25 coiled coil | x-ray diffraction | A, E, I | — | — |
| 5NT2 | Complex of influenza A NS1 with TRIM25 coiled coil domain | x-ray diffraction | I, A, V, N | — | 12 (best 0.79) |
| 5NT2 | Complex of influenza a NS1 with TRIM25 coiled coil domain | x-ray diffraction | I, A, V, N | — | — |
| 6FLM | Crystal structure of the human TRIM25 PRYSPRY domain | x-ray diffraction | A, B, C | SO4, CL | 4 (best 0.72) |
| 6FLM | Crystal structure of the human TRIM25 pryspry domain | x-ray diffraction | A, B, C | SO4, CL | — |
| 6FLN | Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains | x-ray diffraction | A, B, E | — | 4 (best 0.50) |
| 6FLN | Crystal structure of the human TRIM25 coiled-coil and pryspry domains | x-ray diffraction | A, B, E | — | — |
| Q14258 | AlphaFold monomer V2.0 prediction for E3 UBIQUITIN/ISG15 ligase TRIM25 (Q14258) | predicted | A | — | 1 (best 0.30) |
Ligands
Experiment against prediction
- 6FLN chain B against the predicted model Q14258: TM-score 0.99, RMSD 0.74 Å
- 6FLN chain B against the predicted model Q14258: TM-score 0.99, RMSD 0.74 Å
- 6FLM chain A against the predicted model Q14258: TM-score 0.99, RMSD 0.64 Å
- 6FLM chain A against the predicted model Q14258: TM-score 0.99, RMSD 0.64 Å
- 6FLM chain C against the predicted model Q14258: TM-score 0.98, RMSD 0.72 Å
- 6FLM chain C against the predicted model Q14258: TM-score 0.98, RMSD 0.72 Å
- 6FLN chain A against the predicted model Q14258: TM-score 0.98, RMSD 1.02 Å
- 6FLN chain A against the predicted model Q14258: TM-score 0.98, RMSD 1.02 Å
- 6FLN chain E against the predicted model Q14258: TM-score 0.98, RMSD 1.05 Å
- 6FLN chain E against the predicted model Q14258: TM-score 0.98, RMSD 1.05 Å
Elsewhere
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