DDR1, 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-YL)METHYL]-8-(1H-indazole-5- carbonyl)-1-phenyl-1,3,8-TRIAZASPIRO[4.5]DECAN-4-one, 1.670A, P1211, RFREE=22.8%

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 16% strand (DSSP).

Ligands and binding sites

• DJQ · 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1~{H}-indazol-5-ylcarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one · ligand · chains A
• IOD · Iodide ion · ion · 8 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 6FIN · DDR1, 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1… · the same entry in another collection · chain A against A, TM-score 1.00
• Q08345 · AlphaFold monomer V2.0 prediction for epithelial discoidin domain- containing receptor 1… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q08345
• Elsewhere: RCSB PDB 6FIN · PDBe 6FIN · UniProt Q08345