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Crystal structure of the BRI1 GLY644-asp (BRI1-6) mutant from arabidopsis thaliana.
Analyse Crystal structure of the BRI1 GLY644-asp (BRI1-6) mutant from arabidopsis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FIF
- Type
- protein
- Length
- 744 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein brassinosteroid insensitive 1
- EC
- 2.7.10.1, 2.7.11.1
- UniProt
- O22476
- Ligands
- NAG, FUC, BMA
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein brassinosteroid insensitive 1 (EC 2.7.10.1, 2.7.11.1) | protein | 744 | 18% helix, 23% strand | O22476 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 12 copies · chains A
- FUC · alpha-L-fucopyranose · sugar · chains A
- BMA · beta-D-mannopyranose · sugar · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.58 | 0.80 | 21 | empty |
| 2 | 138 | 0.50 | 0.80 | 29 | empty |
| 3 | 87 | 0.37 | 0.76 | 19 | empty |
| 4 | 53 | 0.34 | 0.79 | 17 | EDO |
Modifications
Observed in the structure: 8 disulfide, 8 glycan (disulfide, N-glycosylation).
Compared structures
- 6FIF · Crystal structure of the BRI1 Gly644-Asp (bri1-6) mutant from Arabidopsis thaliana. · the same entry in another collection · chain A against A, TM-score 1.00
- O22476 · AlphaFold monomer V2.0 prediction for protein brassinosteroid insensitive 1 (O22476) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O22476
- Elsewhere: RCSB PDB 6FIF · PDBe 6FIF · UniProt O22476
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