Research workbench
Crystal structure of drosophila neural ectodermal development factor imp-L1 with human igf-I
Analyse Crystal structure of drosophila neural ectodermal development factor imp-L1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FF3
- Type
- protein
- Length
- 247 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NEURAL/ECTODERMAL development factor imp-L2; Insulin-like growth factor I
- UniProt
- Q09024, P05019
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NEURAL/ECTODERMAL development factor imp-L2 | protein | 207 | 3% helix, 55% strand | Q09024 |
| B | Insulin-like growth factor I | protein | 40 | 70% helix, 0% strand | P05019 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.65 | 0.86 | 26 | empty |
| 2 | 76 | 0.33 | 0.75 | 16 | empty |
| 3 | 55 | 0.33 | 0.77 | 13 | empty |
| 4 | 70 | 0.28 | 0.72 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 864 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6FF3 · Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human… · the same entry in another collection · chain A against A, TM-score 1.00
- Q09024 · AlphaFold monomer V2.0 prediction for NEURAL/ECTODERMAL development factor imp-L2 (Q09024) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P05019 · AlphaFold monomer V2.0 prediction for insulin-like growth factor I (P05019) · a predicted model of the same protein · chain B against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09024
- Every structure of UniProt P05019
- Elsewhere: RCSB PDB 6FF3 · PDBe 6FF3 · UniProt Q09024 · UniProt P05019
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