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Crystal structure of human aprt-TYR105PHE variant in complex with adenine, prpp and MG2+, 14 days post crystallization (with AMP and ppi products partially generated)

Analyse Crystal structure of human aprt-TYR105PHE variant in complex with adenine, prpp… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6FD5
Type: protein
Length: 344 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P07741
Ligands: AMP, PPV, PRP, MG

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	173	—	P07741
B	—	protein	171	—	P07741

Ligands and binding sites

AMP · Adenosine monophosphate · ligand · 2 copies · chains A, B
PPV · Pyrophosphate · ligand · 2 copies · chains A, B
PRP · 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose · ligand · chains A, B
MG · Magnesium ion · metal · 2 copies · chains B
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6FD5 · Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+… · the same entry in another collection · chain A against A, TM-score 1.00
P07741 · AlphaFold monomer V2.0 prediction for adenine phosphoribosyltransferase (P07741) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07741
Elsewhere: RCSB PDB 6FD5 · PDBe 6FD5 · UniProt P07741

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