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Co-crystal structure of spop math domain and human PDX1 fragment

Analyse Co-crystal structure of spop math domain and human PDX1 fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6F8F
Type: protein
Length: 147 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Speckle-type poz protein; PANCREAS/DUODENUM homeobox protein 1
UniProt: O43791, P52945

Structure

x-ray diffraction · 2 distinct chains · 13% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	Speckle-type poz protein	protein	137	14% helix, 46% strand	O43791
G	PANCREAS/DUODENUM homeobox protein 1	protein	10	0% helix, 20% strand	P52945

Interfaces

1 interface between chains.

D–G · 635 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6F8F · Co-crystal structure of SPOP MATH domain and human Pdx1 fragment · the same entry in another collection · chain D against D, TM-score 1.00
O43791 · AlphaFold monomer V2.0 prediction for speckle-type poz protein (O43791) · a predicted model of the same protein · chain D against A, TM-score 0.94
P52945 · AlphaFold monomer V2.0 prediction for PANCREAS/DUODENUM homeobox protein 1 (P52945) · a predicted model of the same protein · chain G against A, TM-score 0.29

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43791
Every structure of UniProt P52945
Elsewhere: RCSB PDB 6F8F · PDBe 6F8F · UniProt O43791 · UniProt P52945

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