Research workbench
Structure of the Y21F variant of quinolinate synthase in complex with pgh
Analyse Structure of the Y21F variant of quinolinate synthase in complex with pgh in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6F4D
- Type
- protein
- Length
- 304 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Quinolinate synthase a
- EC
- 2.5.1.72
- UniProt
- Q9X1X7
- Ligands
- SF4, PGH, PO4, CL
- Pockets
- 1 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Quinolinate synthase a (EC 2.5.1.72) | protein | 304 | 47% helix, 16% strand | Q9X1X7 |
Ligands and binding sites
- SF4 · Iron/sulfur cluster · ligand · chains A
- PGH · Phosphoglycolohydroxamic acid · ligand · chains A
- PO4 · Phosphate ion · ion · 2 copies · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.74 | 0.93 | 36 | SF4, PGH, PO4 |
Compared structures
- 6F4D · Structure of the Y21F variant of quinolinate synthase in complex with PGH · the same entry in another collection · chain A against A, TM-score 1.00
- Q9X1X7 · AlphaFold monomer V2.0 prediction for quinolinate synthase a (Q9X1X7) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X1X7
- Elsewhere: RCSB PDB 6F4D · PDBe 6F4D · UniProt Q9X1X7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.