Research workbench
RAS guanine exchange factor SOS1 (rem-CDC25) in complex with KRAS(G12C)
Analyse RAS guanine exchange factor SOS1 (rem-CDC25) in complex with KRAS(G12C) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EPL
- Type
- protein
- Length
- 631 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTPase KRAS; Son of sevenless homolog 1
- UniProt
- P01116, Q07889
- Pockets
- 10 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | GTPase KRAS | protein | 169 | 40% helix, 25% strand | P01116 |
| S | Son of sevenless homolog 1 | protein | 462 | 58% helix, 5% strand | Q07889 |
Ligands and binding sites
- GOL · Glycerol · additive · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 227 | 0.66 | 0.84 | 40 | empty |
| 2 | 314 | 0.62 | 0.79 | 41 | empty |
| 3 | 399 | 0.60 | 0.77 | 61 | empty |
| 4 | 117 | 0.53 | 0.82 | 19 | empty |
| 5 | 129 | 0.43 | 0.76 | 28 | empty |
Interfaces
1 interface between chains.
- R–S · 1734 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6EPL · Ras guanine exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) · the same entry in another collection · chain R against R, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01116
- Every structure of UniProt Q07889
- Elsewhere: RCSB PDB 6EPL · PDBe 6EPL · UniProt P01116 · UniProt Q07889
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.