Research workbench
Enterococcus faecalis fic protein in complex with AMP and calcium ion.
Analyse Enterococcus faecalis fic protein in complex with AMP and calcium ion. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EP0
- Type
- protein
- Length
- 400 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fic family protein
- UniProt
- U6S0Y1
- Ligands
- AMP, CA, CL
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fic family protein | protein | 199 | 59% helix, 4% strand | U6S0Y1 |
| B | Fic family protein | protein | 201 | 58% helix, 4% strand | U6S0Y1 |
Ligands and binding sites
- AMP · Adenosine monophosphate · ligand · 2 copies · chains A, B
- CA · Calcium ion · metal · 6 copies · chains A, B
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1124 | 0.83 | 0.84 | 91 | AMP, CA, CL |
| 2 | 63 | 0.70 | 0.96 | 21 | empty |
| 3 | 52 | 0.65 | 0.95 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1200 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 6EP0 · Enterococcus faecalis FIC protein in complex with AMP and calcium ion. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt U6S0Y1
- Elsewhere: RCSB PDB 6EP0 · PDBe 6EP0 · UniProt U6S0Y1
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