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Structure of inorganic pyrophosphatase mutant D70N

Analyse Structure of inorganic pyrophosphatase mutant D70N in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1MJY
Type: protein
Length: 350 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inorganic pyrophosphatase
EC: 3.6.1.1
UniProt: P0A7A9
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 20% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Inorganic pyrophosphatase (EC 3.6.1.1)	protein	175	20% helix, 34% strand	P0A7A9

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	734	0.68	0.75	44	empty
2	114	0.47	0.80	23	empty
3	63	0.42	0.81	22	empty
4	58	0.34	0.77	14	empty

Interfaces

1 interface between chains.

A–B · 200 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1MJY · Structure of inorganic pyrophosphatase mutant D70N · the same entry in another collection · chain A against A, TM-score 1.00
P0A7A9 · AlphaFold monomer V2.0 prediction for inorganic pyrophosphatase (P0A7A9) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A7A9
Elsewhere: RCSB PDB 1MJY · PDBe 1MJY · UniProt P0A7A9

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