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Crystal structure of human respiratory syncytial virus fusion glycoprotein inhibitor escape variant L141W stabilized in the prefusion state

Analyse Crystal structure of human respiratory syncytial virus fusion glycoprotein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6EAE
Type: protein
Length: 451 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fusion glycoprotein F0
UniProt: W8RJF9
Ligands: SO4
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
F	Fusion glycoprotein F0	protein	451	30% helix, 33% strand	W8RJF9

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains F
NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · 2 copies · chains F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	132	0.42	0.75	23	empty
2	64	0.36	0.78	14	empty

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

6EAE · Crystal structure of human respiratory syncytial virus fusion glycoprotein inhibitor… · the same entry in another collection · chain F against F, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt W8RJF9
Elsewhere: RCSB PDB 6EAE · PDBe 6EAE · UniProt W8RJF9

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