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Solution structure of ZZZ3 zz domain in complex with histone H3K4AC peptide

Analyse Solution structure of ZZZ3 zz domain in complex with histone H3K4AC peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6E86
Type: protein
Length: 72 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zz-type zinc finger-containing protein 3; H3K4AC
UniProt: Q8IYH5
Ligands: ZN

Structure

solution nmr · 2 distinct chains · 4% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Zz-type zinc finger-containing protein 3	protein	64	5% helix, 23% strand	Q8IYH5
A	H3K4AC	protein	8	0% helix, 13% strand	—

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

B–A · 284 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (acetylation).

Compared structures

6E86 · Solution structure of ZZZ3 ZZ domain in complex with histone H3K4ac peptide · the same entry in another collection · chain B against B, TM-score 1.00
Q8IYH5 · AlphaFold monomer V2.0 prediction for zz-type zinc finger-containing protein 3 (Q8IYH5) · a predicted model of the same protein · chain B against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IYH5
Elsewhere: RCSB PDB 6E86 · PDBe 6E86 · UniProt Q8IYH5

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