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Crystal structure of an integrin BETA3-talin chimera

Analyse Crystal structure of an integrin BETA3-talin chimera in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1MIZ
Type: protein
Length: 210 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Integrin BETA3; Talin
UniProt: P05106, P54939
Pockets: 1 · best druggability 0.26

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Integrin BETA3	protein	9	0% helix, 0% strand	P05106
B	Talin	protein	201	40% helix, 20% strand	P54939

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.26	0.73	11	empty

Interfaces

1 interface between chains.

A–B · 157 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1MIZ · Crystal structure of an integrin beta3-talin chimera · the same entry in another collection · chain A against A, TM-score 1.00
P54939 · AlphaFold monomer V2.0 prediction for talin-1 (P54939) · a predicted model of the same protein · chain B against A, TM-score 0.89
P05106 · AlphaFold monomer V2.0 prediction for integrin beta-3 (P05106) · a predicted model of the same protein · chain A against A, TM-score 0.44

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05106
Every structure of UniProt P54939
Elsewhere: RCSB PDB 1MIZ · PDBe 1MIZ · UniProt P05106 · UniProt P54939

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