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Crystal structure of the murine norovirus VP1 P domain in complex with the CD300LF receptor and lithocholic acid

Analyse Crystal structure of the murine norovirus VP1 P domain in complex with the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6E48
Type: protein
Length: 830 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q80J94, Q6SJQ7
Ligands: 4OA, CA

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	304	—	Q80J94
B	—	protein	302	—	Q80J94
F	—	protein	113	—	Q6SJQ7
G	—	protein	111	—	Q6SJQ7

Ligands and binding sites

4OA · (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid · ligand · 2 copies · chains A, B
CA · Calcium ion · metal · 6 copies · chains A, B, G, F
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6E48 · Crystal Structure of the Murine Norovirus VP1 P domain in complex with the CD300lf… · the same entry in another collection · chain A against A, TM-score 1.00
Q6SJQ7 · AlphaFold monomer V2.0 prediction for CMRF35-like molecule 1 (Q6SJQ7) · a predicted model of the same protein · chain G against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q80J94
Every structure of UniProt Q6SJQ7
Elsewhere: RCSB PDB 6E48 · PDBe 6E48 · UniProt Q80J94 · UniProt Q6SJQ7

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