Research workbench
Amidobenzimidazole (abzi) sting agonists
Analyse Amidobenzimidazole (abzi) sting agonists in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DXG
- Type
- protein
- Length
- 177 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stimulator of interferon protein
- UniProt
- A0A2R3XZB7
- Ligands
- HGJ, CA
- Pockets
- 2 · best druggability 0.33
Structure
x-ray diffraction · 1 distinct chain · 54% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Stimulator of interferon protein | protein | 177 | 54% helix, 20% strand | A0A2R3XZB7 |
Ligands and binding sites
- HGJ · 2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-1-[(2R)-2-hydroxy-2-phenylethyl]-1H-benzimidazole-5-carboxamide · ligand · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 84 | 0.33 | 0.74 | 16 | empty |
| 2 | 52 | 0.25 | 0.73 | 13 | empty |
Compared structures
- 6DXG · amidobenzimidazole (ABZI) STING agonists · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2R3XZB7
- Elsewhere: RCSB PDB 6DXG · PDBe 6DXG · UniProt A0A2R3XZB7
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