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Crystal structure of the viral otu domain protease from farallon virus

Analyse Crystal structure of the viral otu domain protease from farallon virus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6DX5
Type: protein
Length: 338 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-dependent RNA polymerase
UniProt: A0A191KW96
Pockets: 3 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	RNA-dependent RNA polymerase	protein	169	46% helix, 24% strand	A0A191KW96

Ligands and binding sites

DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · 3 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	207	0.55	0.79	30	empty
2	117	0.41	0.76	30	empty
3	61	0.35	0.77	15	empty

Interfaces

1 interface between chains.

B–A · 279 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6DX5 · Crystal structure of the viral OTU domain protease from Farallon virus · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A191KW96
Elsewhere: RCSB PDB 6DX5 · PDBe 6DX5 · UniProt A0A191KW96

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