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Linked KDM5A jmj domain bound to the inhibitor N50 I.E. 2-(4-((2- (DIMETHYLAMINO)ETHYL)(ETHYL)CARBAMOYL)-5-(4-methoxyphenyl)-1H- pyrazol-1-YL)ISONICOTINIC acid

Analyse Linked KDM5A jmj domain bound to the inhibitor N50 I.E. 2-(4-((2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6DQC
Type: protein
Length: 311 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P29375
Ligands: H5Y, MN, SO4

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	311	—	P29375

Ligands and binding sites

H5Y · 2-[4-{[2-(dimethylamino)ethyl](ethyl)carbamoyl}-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]pyridine-4-carboxylic acid · ligand · chains A
MN · Manganese (II) ion · metal · chains A
SO4 · Sulfate ion · ion · chains A
DMS · Dimethyl sulfoxide · additive · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6DQC · LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N50 i.e.… · the same entry in another collection · chain A against A, TM-score 1.00
P29375 · AlphaFold monomer V2.0 prediction for lysine-specific demethylase 5A (P29375) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29375
Elsewhere: RCSB PDB 6DQC · PDBe 6DQC · UniProt P29375

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