Research workbench

HBZ56 in complex with kix and C-myb

Analyse HBZ56 in complex with kix and C-myb in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6DMX
Type: protein
Length: 506 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bzip factor; Transcriptional activator myb; Creb-binding protein
EC: 2.3.1.48
UniProt: Q2Q067, P06876, P45481
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 9 distinct chains · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E	Bzip factor	protein	44	91% helix, 0% strand	Q2Q067
C	Transcriptional activator myb	protein	25	52% helix, 0% strand	P06876
D, I	Creb-binding protein (EC 2.3.1.48)	protein	81	78% helix, 0% strand	P45481
A	Transcriptional activator myb	protein	24	54% helix, 0% strand	P06876
B	Creb-binding protein (EC 2.3.1.48)	protein	84	79% helix, 0% strand	P45481
J	Bzip factor	protein	39	92% helix, 0% strand	Q2Q067
H	Transcriptional activator myb	protein	23	57% helix, 0% strand	P06876
F	Transcriptional activator myb	protein	22	64% helix, 0% strand	P06876
G	Creb-binding protein (EC 2.3.1.48)	protein	83	80% helix, 0% strand	P45481

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	672	0.76	0.81	63	empty
2	354	0.60	0.77	31	empty
3	248	0.49	0.74	34	empty
4	69	0.37	0.78	15	empty
5	65	0.30	0.74	11	empty

Interfaces

16 interfaces between chains.

E–D · 910 Å² buried · 9 hydrogen bonds · protein-protein
E–B · 900 Å² buried · 8 hydrogen bonds · protein-protein
J–I · 860 Å² buried · 6 hydrogen bonds · protein-protein
J–G · 853 Å² buried · 15 hydrogen bonds · protein-protein
H–I · 813 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6DMX · HBZ56 in complex with KIX and c-Myb · the same entry in another collection · chain G against G, TM-score 1.00
P45481 · AlphaFold monomer V2.0 prediction for histone lysine acetyltransferase crebbp (P45481) · a predicted model of the same protein · chain B against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2Q067
Every structure of UniProt P06876
Every structure of UniProt P45481
Elsewhere: RCSB PDB 6DMX · PDBe 6DMX · UniProt Q2Q067 · UniProt P06876 · UniProt P45481

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