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Crystal structure of LRRK2 WD40 domain dimer
Analyse Crystal structure of LRRK2 WD40 domain dimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DLO
- Type
- protein
- Length
- 621 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-rich repeat SERINE/THREONINE-protein kinase 2
- EC
- 2.7.11.1
- UniProt
- Q5S007
- Pockets
- 5 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Leucine-rich repeat SERINE/THREONINE-protein kinase 2 (EC 2.7.11.1) | protein | 310 | 6% helix, 52% strand | Q5S007 |
| A | Leucine-rich repeat SERINE/THREONINE-protein kinase 2 (EC 2.7.11.1) | protein | 311 | 4% helix, 53% strand | Q5S007 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 797 | 0.73 | 0.78 | 47 | empty |
| 2 | 863 | 0.73 | 0.77 | 60 | empty |
| 3 | 96 | 0.40 | 0.77 | 20 | empty |
| 4 | 63 | 0.33 | 0.76 | 14 | empty |
| 5 | 72 | 0.31 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- B–A · 1055 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5S007
- Elsewhere: RCSB PDB 6DLO · PDBe 6DLO · UniProt Q5S007
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