Research workbench
Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the basal state
Analyse Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DDO
- Type
- protein
- Length
- 990 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytosolic purine 5'-nucleotidase
- EC
- 3.1.3.5
- UniProt
- P49902
- Ligands
- PO4
- Pockets
- 14 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) | protein | 500 | 38% helix, 17% strand | P49902 |
| B | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) | protein | 490 | 37% helix, 17% strand | P49902 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 612 | 0.67 | 0.77 | 61 | PO4 |
| 2 | 351 | 0.67 | 0.81 | 49 | empty |
| 3 | 401 | 0.66 | 0.79 | 45 | PO4 |
| 4 | 349 | 0.65 | 0.79 | 48 | empty |
| 5 | 399 | 0.63 | 0.78 | 39 | PO4 |
Interfaces
1 interface between chains.
- A–B · 1274 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6DDO · Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the basal state · the same entry in another collection · chain A against A, TM-score 1.00
- P49902 · AlphaFold monomer V2.0 prediction for cytosolic purine 5'-nucleotidase (P49902) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49902
- Elsewhere: RCSB PDB 6DDO · PDBe 6DDO · UniProt P49902
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