UniProt P49902
Cytosolic purine 5'-nucleotidase (P49902)
Cytosolic purine 5'-nucleotidase (UniProt P49902), EC 3.1.3.5: 74 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 106 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P49902
- Protein
- Cytosolic purine 5'-nucleotidase
- EC
- 3.1.3.5
- Experimental structures
- 74
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 106 · 15 records with a druggable one
Structures
75 records of P49902 in the MolNFT archive: 74 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2J2C | Crystal structure of Human Cytosolic 5'-Nucleotidase II (NT5C2, cN-II) | x-ray diffraction | A | — | — |
| 2J2C | Crystal structure of human cytosolic 5'-nucleotidase II (NT5C2, cn-II) | x-ray diffraction | A | — | — |
| 2JC9 | Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine | x-ray diffraction | A | — | — |
| 2JC9 | Crystal structure of human cytosolic 5'-nucleotidase II in complex with adenosine | x-ray diffraction | A | — | — |
| 2JCM | Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with beryllium trifluoride | x-ray diffraction | A | — | — |
| 2JCM | Crystal structure of human cytosolic 5'-nucleotidase II in complex with beryllium trifluoride | x-ray diffraction | A | — | — |
| 2XCV | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inosine… | x-ray diffraction | A | — | — |
| 2XCV | Crystal structure of the D52N variant of cytosolic 5'- nucleotidase II in complex with inosine… | x-ray diffraction | A | — | — |
| 2XCW | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inosine… | x-ray diffraction | A | — | — |
| 2XCW | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inosine… | x-ray diffraction | A | — | — |
| 2XCX | Crystal structure of the apoform of the D52N variant of cytosolic 5'- nucleotidase II | x-ray diffraction | A | — | — |
| 2XCX | Crystal structure of the apoform of the D52N variant of cytosolic 5'- nucleotidase II | x-ray diffraction | A | — | — |
| 2XJB | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with… | x-ray diffraction | A | — | — |
| 2XJB | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with… | x-ray diffraction | A | — | — |
| 2XJC | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with guanosine… | x-ray diffraction | A | — | — |
| 2XJC | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with guanosine… | x-ray diffraction | A | — | — |
| 2XJD | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inorganic… | x-ray diffraction | A | — | — |
| 2XJD | Crystal structure of the D52N variant of cytosolic 5'- nucleotidase II in complex with inorganic… | x-ray diffraction | A | — | — |
| 2XJE | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with uridine… | x-ray diffraction | A | — | — |
| 2XJE | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with uridine… | x-ray diffraction | A | — | — |
| 2XJF | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II with a covalently modified… | x-ray diffraction | A | — | — |
| 2XJF | Crystal structure of the D52N variant of cytosolic 5'- nucleotidase II with a covalently modified… | x-ray diffraction | A | — | — |
| 4H4B | Human cytosolic 5'-nucleotidase II in complex with Anthraqui -2,6- disulfonic acid | x-ray diffraction | A | — | — |
| 4H4B | Human cytosolic 5'-nucleotidase II in complex with anthraquinone-2,6- disulfonic acid | x-ray diffraction | A | — | — |
| 5CQZ | Human cytosolic 5'-nucleotidase II in complex with 3-(3-imidazol-1… | x-ray diffraction | A, B | — | — |
| 5CR7 | Human cytosolic 5'-nucleotidase II in complex with N-(9H-purin-6-yl)… | x-ray diffraction | A, B | — | — |
| 5K7Y | Crystal structure of enzyme in purine metabolism | x-ray diffraction | A | — | — |
| 5K7Y | Crystal structure of enzyme in purine metabolism | x-ray diffraction | A | — | — |
| 5L4Z | Crystal structure of enzyme in purine metabolism | x-ray diffraction | A | — | — |
| 5L50 | Crystal structure of enzyme in purine metabolism | x-ray diffraction | A | — | 6 (best 0.71) |
| 5L50 | Crystal structure of enzyme in purine metabolism | x-ray diffraction | A | — | — |
| 5OPK | Crystal structure of D52N/R367Q cN-II mutant bound to dATP and free phosphate | x-ray diffraction | A | PO4, MG, DTP | — |
| 5OPK | Crystal structure of D52N/R367Q cn-II mutant bound to datp and free phosphate | x-ray diffraction | A | PO4, MG, DTP | — |
| 5OPL | Crystal structure of K25E cN-II mutant | x-ray diffraction | A | MG | 5 (best 0.70) |
| 5OPL | Crystal structure of K25E cn-II mutant | x-ray diffraction | A | MG | — |
| 5OPM | Crystal structure of D52N/R238W cn-II mutant bound to datp and free phosphate | x-ray diffraction | A | PO4, MG, DTP | — |
| 5OPN | Crystal structure of R39Q cN-II mutant | x-ray diffraction | A | — | — |
| 5OPN | Crystal structure of R39Q cn-II mutant | x-ray diffraction | A | — | — |
| 5OPO | Crystal structure of R238G cN-II mutant | x-ray diffraction | A | MG | 5 (best 0.70) |
| 5OPO | Crystal structure of R238G cn-II mutant | x-ray diffraction | A | MG | — |
| 5OPP | Crystal structure of S408R cN-II mutant | x-ray diffraction | A | MG, BR | 5 (best 0.68) |
| 5OPP | Crystal structure of S408R cn-II mutant | x-ray diffraction | A | MG, BR | — |
| 6DD3 | Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state | x-ray diffraction | A | PO4 | — |
| 6DDB | Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the basal state, northeast… | x-ray diffraction | A, B | MN, PO4 | — |
| 6DDC | Crystal structure of the single mutant (D52N) of NT5C2-537X in the basal state, Northeast… | x-ray diffraction | A, B | MG, PO4 | 12 (best 0.83) |
| 6DDC | Crystal structure of the single mutant (D52N) of NT5C2-537X in the basal state, northeast… | x-ray diffraction | A, B | MG, PO4 | — |
| 6DDH | Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the active state, northeast… | x-ray diffraction | A | IMP | — |
| 6DDK | Crystal structure of the double mutant (D52N/R367Q) of the full-length NT5C2 in the basal state | x-ray diffraction | A, B | PO4 | 15 (best 0.70) |
| 6DDK | Crystal structure of the double mutant (D52N/R367Q) of the full-length NT5C2 in the basal state | x-ray diffraction | A, B | PO4 | — |
| 6DDL | Crystal structure of the single mutant (D52N) of NT5C2-Q523X in the basal state | x-ray diffraction | A, B | PO4 | — |
| 6DDO | Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the basal state | x-ray diffraction | A, B | PO4 | 14 (best 0.67) |
| 6DDO | Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the basal state | x-ray diffraction | A, B | PO4 | — |
| 6DDQ | Crystal structure of the double mutant (R39Q/D52N) of the full-length NT5C2 in the basal state | x-ray diffraction | A, B | PO4 | — |
| 6DDX | Crystal structure of the double mutant (D52N/L375F) of NT5C2-537X in the active state, Northeast… | x-ray diffraction | A | PO4 | 5 (best 0.67) |
| 6DDX | Crystal structure of the double mutant (D52N/L375F) of NT5C2-537X in the active state, northeast… | x-ray diffraction | A | PO4 | — |
| 6DDY | Crystal structure of the double mutant (D52N/K359Q) of NT5C2-537X in the active state, northeast… | x-ray diffraction | A | PO4 | — |
| 6DDZ | Crystal structure of the double mutant (D52N/R238W) of NT5C2-537X in the active state, Northeast… | x-ray diffraction | A | ATP, PO4, MG | — |
| 6DDZ | Crystal structure of the double mutant (D52N/R238W) of NT5C2-537X in the active state, northeast… | x-ray diffraction | A | ATP, PO4, MG | — |
| 6DE0 | Crystal structure of the single mutant (D52N) of NT5C2-Q523X in the active state | x-ray diffraction | A | PO4 | 6 (best 0.70) |
| 6DE0 | Crystal structure of the single mutant (D52N) of NT5C2-Q523X in the active state | x-ray diffraction | A | PO4 | — |
15 records more on the page itself.
Ligands
- PO4 · Phosphate ion · in 25 records
- MG · Magnesium ion · in 24 records
- SO4 · Sulfate ion · in 9 records
- ATP · Adenosine-5'-triphosphate · in 6 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 3 records
- BR · Bromide ion · in 2 records
- IMP · Inosinic acid · in 1 record
- MN · Manganese (II) ion · in 1 record
Experiment against prediction
- 6DDL chain A against the predicted model P49902: TM-score 0.98, RMSD 1.07 Å
- 5CQZ chain B against the predicted model P49902: TM-score 0.98, RMSD 1.04 Å
- 5CR7 chain B against the predicted model P49902: TM-score 0.98, RMSD 1.13 Å
- 5CR7 chain A against the predicted model P49902: TM-score 0.98, RMSD 1.21 Å
- 5CQZ chain A against the predicted model P49902: TM-score 0.98, RMSD 1.23 Å
- 6DDL chain B against the predicted model P49902: TM-score 0.98, RMSD 1.26 Å
- 6DDB chain A against the predicted model P49902: TM-score 0.98, RMSD 1.27 Å
- 6DDC chain A against the predicted model P49902: TM-score 0.98, RMSD 1.22 Å
- 6DDC chain A against the predicted model P49902: TM-score 0.98, RMSD 1.22 Å
- 6DDB chain B against the predicted model P49902: TM-score 0.98, RMSD 1.27 Å
Elsewhere
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