Research workbench
Crystal structure of the W184R/W231R importin alpha mutant
Analyse Crystal structure of the W184R/W231R importin alpha mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6D7M
- Type
- protein
- Length
- 424 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PEROXIDASE,IMPORTIN subunit alpha-1
- EC
- 1.11.1.7
- UniProt
- P52293
- Ligands
- CL
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | PEROXIDASE,IMPORTIN subunit alpha-1 (EC 1.11.1.7) | protein | 424 | 74% helix, 0% strand | P52293 |
Ligands and binding sites
- CL · Chloride ion · ion · chains B
- EDO · 1,2-ethanediol · additive · 3 copies · chains B
- SIN · Succinic acid · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.40 | 0.80 | 14 | empty |
Compared structures
- 6D7M · Crystal structure of the W184R/W231R Importin alpha mutant · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Elsewhere: RCSB PDB 6D7M · PDBe 6D7M · UniProt P52293
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