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Crystal structure of unphosphorylated human pkr
Analyse Crystal structure of unphosphorylated human pkr in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6D3L
- Type
- protein
- Length
- 248 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon-induced, double-stranded RNA-activated protein kinase
- EC
- 2.7.11.1, 2.7.10.2
- UniProt
- P19525
- Pockets
- 2 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1, 2.7.10.2) | protein | 248 | 35% helix, 23% strand | P19525 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 282 | 0.62 | 0.79 | 37 | empty |
| 2 | 106 | 0.45 | 0.78 | 24 | empty |
Compared structures
- 6D3L · Crystal structure of unphosphorylated human PKR · the same entry in another collection · chain A against A, TM-score 1.00
- P19525 · AlphaFold monomer V2.0 prediction for interferon-induced, double- stranded RNA-activated… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19525
- Elsewhere: RCSB PDB 6D3L · PDBe 6D3L · UniProt P19525
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