UniProt P19525
Interferon-induced, double-stranded RNA-activated protein kinase (P19525)
Interferon-induced, double-stranded RNA-activated protein kinase (UniProt P19525), EC 2.7.10.2, 2.7.11.1: 18 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 11 pockets. Binding sites, druggability and…
- UniProt
- P19525
- Protein
- Interferon-induced, double-stranded RNA-activated protein kinase
- EC
- 2.7.10.2, 2.7.11.1
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 11 · 4 records with a druggable one
Structures
19 records of P19525 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1QU6 | Structure of the double-stranded RNA-binding domain of the protein kinase pkr reveals the molecular… | solution nmr | A | — | — |
| 1QU6 | Structure of the double-stranded RNA-binding domain of the protein kinase pkr reveals the molecular… | solution nmr | A | — | — |
| 2A19 | PKR kinase domain- eIF2alpha- AMP-PNP complex. | x-ray diffraction | B, C | — | — |
| 2A19 | Pkr kinase domain- EIF2ALPHA- AMP-pnp complex. | x-ray diffraction | B, C | — | — |
| 2A1A | PKR kinase domain-eIF2alpha Complex | x-ray diffraction | B | — | — |
| 2A1A | Pkr kinase domain-EIF2ALPHA complex | x-ray diffraction | B | — | — |
| 3UIU | Crystal structure of Apo-PKR kinase domain | x-ray diffraction | A, B | — | — |
| 3UIU | Crystal structure of apo-pkr kinase domain | x-ray diffraction | A, B | — | — |
| 6D3K | Crystal structure of unphosphorylated human pkr kinase domain in complex with ADP | x-ray diffraction | B, A, C | ADP, PO4, MG, SO4 | — |
| 6D3L | Crystal structure of unphosphorylated human pkr | x-ray diffraction | A | — | — |
| 6NPY | Cryo-EM structure of NLRP3 bound to NEK7 | electron microscopy | B | — | 6 (best 0.88) |
| 6NPY | Cryo-EM structure of NLRP3 bound to NEK7 | electron microscopy | B | — | — |
| 7OBK | Crystal structure of 14-3-3 sigma in complex with pkr phosphopeptide | x-ray diffraction | B | — | — |
| 7OBL | Crystal structure of 14-3-3 sigma in complex with PKR phosphopeptide and stabilizer Fusicoccin-A | x-ray diffraction | B | FSC | 1 (best 0.53) |
| 7OBL | Crystal structure of 14-3-3 sigma in complex with pkr phosphopeptide and stabilizer fusicoccin-a | x-ray diffraction | B | FSC | — |
| 8BI7 | Binary structure of 14-3-3s and PKR phosphopeptide | x-ray diffraction | B | — | 1 (best 0.50) |
| 8IZN | Structural study of Interferon-induced, double-stranded RNA-activated protein kinase (PKR) and… | electron microscopy | A | — | 1 (best 0.46) |
| 8QEL | PKR kinase domain- eIF2alpha in complex with compound | x-ray diffraction | B | UH3 | 2 (best 0.77) |
| P19525 | AlphaFold monomer V2.0 prediction for interferon-induced, double- stranded RNA-activated protein… | predicted | A | — | — |
Ligands
Experiment against prediction
- 2A19 chain B against the predicted model P19525: TM-score 0.99, RMSD 0.77 Å
- 2A19 chain B against the predicted model P19525: TM-score 0.99, RMSD 0.77 Å
- 6D3K chain C against the predicted model P19525: TM-score 0.98, RMSD 1.09 Å
- 8QEL chain B against the predicted model P19525: TM-score 0.97, RMSD 1.06 Å
- 2A1A chain B against the predicted model P19525: TM-score 0.97, RMSD 1.19 Å
- 2A1A chain B against the predicted model P19525: TM-score 0.97, RMSD 1.19 Å
- 2A19 chain C against the predicted model P19525: TM-score 0.96, RMSD 1.07 Å
- 2A19 chain C against the predicted model P19525: TM-score 0.96, RMSD 1.07 Å
- 6D3L chain A against the predicted model P19525: TM-score 0.96, RMSD 1.21 Å
- 3UIU chain B against the predicted model P19525: TM-score 0.96, RMSD 1.54 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.