Research workbench
Structure of human ARH3 bound to ADP-ribose and magnesium
Analyse Structure of human ARH3 bound to ADP-ribose and magnesium in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6D36
- Type
- protein
- Length
- 1,352 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- POLY(ADP-ribose) glycohydrolase ARH3
- EC
- 3.2.1.143
- UniProt
- Q9NX46
- Ligands
- AR6, MG
- Pockets
- 17 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 67% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | POLY(ADP-ribose) glycohydrolase ARH3 (EC 3.2.1.143) | protein | 338 | 68% helix, 1% strand | Q9NX46 |
| D | POLY(ADP-ribose) glycohydrolase ARH3 (EC 3.2.1.143) | protein | 336 | 67% helix, 1% strand | Q9NX46 |
| A | POLY(ADP-ribose) glycohydrolase ARH3 (EC 3.2.1.143) | protein | 345 | 66% helix, 1% strand | Q9NX46 |
| B | POLY(ADP-ribose) glycohydrolase ARH3 (EC 3.2.1.143) | protein | 333 | 68% helix, 1% strand | Q9NX46 |
Ligands and binding sites
- AR6 · [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · ligand · 4 copies · chains C, D, A, B
- MG · Magnesium ion · metal · 8 copies · chains C, D, A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 303 | 0.77 | 0.89 | 54 | empty |
| 2 | 319 | 0.77 | 0.88 | 51 | empty |
| 3 | 64 | 0.73 | 0.98 | 20 | empty |
| 4 | 59 | 0.73 | 0.99 | 20 | empty |
| 5 | 60 | 0.73 | 0.98 | 20 | empty |
Interfaces
2 interfaces between chains.
- C–D · 987 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 944 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NX46
- Elsewhere: RCSB PDB 6D36 · PDBe 6D36 · UniProt Q9NX46
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