UniProt Q9NX46
ADP-ribose glycohydrolase ARH3 (Q9NX46)
ADP-ribose glycohydrolase ARH3 (UniProt Q9NX46), EC 3.2.1.143, 3.2.2.-: 19 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 110 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9NX46
- Protein
- ADP-ribose glycohydrolase ARH3
- EC
- 3.2.1.143, 3.2.2.-, 3.5.1.-
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 110 · 8 records with a druggable one
Structures
20 records of Q9NX46 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FOZ | human ADP-ribosylhydrolase 3 | x-ray diffraction | A | — | — |
| 2FOZ | Human ADP-ribosylhydrolase 3 | x-ray diffraction | A | — | — |
| 2FP0 | human ADP-ribosylhydrolase 3 | x-ray diffraction | A, B | — | — |
| 2FP0 | Human ADP-ribosylhydrolase 3 | x-ray diffraction | A, B | — | — |
| 5ZQY | Crystal structure of a poly(ADP-ribose) glycohydrolase | x-ray diffraction | A | MG, AR6 | 2 (best 0.52) |
| 5ZQY | Crystal structure of a POLY(ADP-ribose) glycohydrolase | x-ray diffraction | A | MG, AR6 | — |
| 6D36 | Structure of human ARH3 bound to ADP-ribose and magnesium | x-ray diffraction | C, D, A, B | AR6, MG | 17 (best 0.77) |
| 6D36 | Structure of human ARH3 bound to ADP-ribose and magnesium | x-ray diffraction | C, D, A, B | AR6, MG | — |
| 6D3A | Structure of human ARH3 D314E bound to ADP-ribose and magnesium | x-ray diffraction | C, D, A, B | AR6, MG | 15 (best 0.77) |
| 6D3A | Structure of human ARH3 D314E bound to ADP-ribose and magnesium | x-ray diffraction | C, D, A, B | AR6, MG | — |
| 7AKR | Human ADP-ribosylserine hydrolase ARH3 mutant E41A in complex with ADP-ribose dimer | x-ray diffraction | AAA, BBB, CCC, DDD | MG, AR6, CL | 12 (best 0.72) |
| 7AKS | Human ADP-ribosylserine hydrolase ARH3 mutant E41A in complex with H2B-S7-mar peptide | x-ray diffraction | AAA, CCC, EEE, GGG | MG, AR6 | 15 (best 0.88) |
| 7ARW | Structure of human ARH3 E41A bound to alpha-NAD+ and magnesium | x-ray diffraction | A, B | MG, 8NA | — |
| 7L9F | Crystal structure of human ARH3 bound to calcium and ADP-ribose | x-ray diffraction | C, D, A, B | AR6, CA | 16 (best 0.77) |
| 7L9F | Crystal structure of human ARH3 bound to calcium and ADP-ribose | x-ray diffraction | C, D, A, B | AR6, CA | — |
| 7L9H | Crystal structure of human ARH3-D77A bound to magnesium and ADP-ribose | x-ray diffraction | C, D, A, B | AR6, MG | 17 (best 0.77) |
| 7L9H | Crystal structure of human ARH3-D77A bound to magnesium and ADP-ribose | x-ray diffraction | C, D, A, B | AR6, MG | — |
| 7L9I | Crystal structure of human ARH3-D314A bound to magnesium and ADP-ribose | x-ray diffraction | C, D, A, B | AR6, MG | 16 (best 0.76) |
| 7L9I | Crystal structure of human ARH3-D314A bound to magnesium and ADP- ribose | x-ray diffraction | C, D, A, B | AR6, MG | — |
| Q9NX46 | AlphaFold monomer V2.0 prediction for ADP-ribose glycohydrolase ARH3 (Q9NX46) | predicted | A | — | — |
Ligands
- AR6 · [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · in 14 records
- MG · Magnesium ion · in 13 records
- CA · Calcium ion · in 2 records
- 8NA · Alpha-diphosphopyridine nucleotide · in 1 record
- CL · Chloride ion · in 1 record
Experiment against prediction
- 5ZQY chain A against the predicted model Q9NX46: TM-score 1.00, RMSD 0.45 Å
- 5ZQY chain A against the predicted model Q9NX46: TM-score 1.00, RMSD 0.45 Å
- 7AKR chain DDD against the predicted model Q9NX46: TM-score 0.99, RMSD 0.58 Å
- 7AKR chain AAA against the predicted model Q9NX46: TM-score 0.99, RMSD 0.65 Å
- 6D3A chain C against the predicted model Q9NX46: TM-score 0.99, RMSD 0.67 Å
- 6D3A chain C against the predicted model Q9NX46: TM-score 0.99, RMSD 0.67 Å
- 7L9I chain C against the predicted model Q9NX46: TM-score 0.99, RMSD 0.68 Å
- 7L9I chain C against the predicted model Q9NX46: TM-score 0.99, RMSD 0.68 Å
- 7L9H chain C against the predicted model Q9NX46: TM-score 0.99, RMSD 0.68 Å
- 7L9H chain C against the predicted model Q9NX46: TM-score 0.99, RMSD 0.68 Å
Elsewhere
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