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Human clc-1 chloride ion channel, C-terminal cytosolic domain

Analyse Human clc-1 chloride ion channel, C-terminal cytosolic domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6COZ
Type: protein
Length: 320 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chloride channel protein 1
UniProt: P35523
Pockets: 5 · best druggability 0.64

Structure

electron microscopy · 1 distinct chain · 38% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Chloride channel protein 1	protein	160	38% helix, 19% strand	P35523

Pockets

5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	326	0.64	0.80	50	empty
2	334	0.63	0.80	54	empty
3	303	0.62	0.80	51	empty
4	327	0.62	0.79	60	empty
5	274	0.57	0.78	50	empty

Interfaces

1 interface between chains.

A–B · 137 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6COZ · Human CLC-1 chloride ion channel, C-terminal cytosolic domain · the same entry in another collection · chain A against A, TM-score 1.00
P35523 · AlphaFold monomer V2.0 prediction for chloride channel protein 1 (P35523) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35523
Elsewhere: RCSB PDB 6COZ · PDBe 6COZ · UniProt P35523

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