Research workbench

Barium sites in the structure of a desensitized acid sensing ion channel

Analyse Barium sites in the structure of a desensitized acid sensing ion channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6CMC
Type: protein
Length: 414 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acid-sensing ion channel 1
UniProt: Q1XA76
Ligands: CL
Pockets: 3 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Acid-sensing ion channel 1	protein	414	34% helix, 25% strand	Q1XA76

Ligands and binding sites

CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	241	0.63	0.81	38	empty
2	207	0.53	0.78	32	empty
3	81	0.38	0.77	12	empty

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

6CMC · Barium sites in the structure of a desensitized acid sensing ion channel · the same entry in another collection · chain A against A, TM-score 1.00
Q1XA76 · AlphaFold monomer V2.0 prediction for acid-sensing ion channel 1 (Q1XA76) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q1XA76
Elsewhere: RCSB PDB 6CMC · PDBe 6CMC · UniProt Q1XA76

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.