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Crystal structure of a Fc fragment lala mutant (L234A, L235A) of human IGG1 (crystal form 2)
Analyse Crystal structure of a Fc fragment lala mutant (L234A, L235A) of human IGG1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CJX
- Type
- protein
- Length
- 417 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fc fragment of human IGG1
- UniProt
- Q6MZV7
- Ligands
- NAG, MAN, BMA, FUC
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fc fragment of human IGG1 | protein | 208 | 12% helix, 49% strand | Q6MZV7 |
| B | Fc fragment of human IGG1 | protein | 209 | 11% helix, 46% strand | Q6MZV7 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 4 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 2 copies · chains A, B
- FUC · alpha-L-fucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.34 | 0.74 | 22 | empty |
| 2 | 63 | 0.33 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1180 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 6CJX · Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6MZV7
- Elsewhere: RCSB PDB 6CJX · PDBe 6CJX · UniProt Q6MZV7
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