Research workbench
Regulatory segment of mouse 3',5'-cyclic nucleotide phosphodiesterase 2A, containing the gaf a and gaf B domains
Analyse Regulatory segment of mouse 3',5'-cyclic nucleotide phosphodiesterase 2A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1MC0
- Type
- protein
- Length
- 341 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3',5'-cyclic nucleotide phosphodiesterase 2A
- EC
- 3.1.4.35
- UniProt
- Q922S4
- Ligands
- PCG
- Pockets
- 2 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3',5'-cyclic nucleotide phosphodiesterase 2A (EC 3.1.4.35) | protein | 341 | 44% helix, 25% strand | Q922S4 |
Ligands and binding sites
- PCG · Cyclic guanosine monophosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.77 | 0.95 | 23 | PCG |
| 2 | 232 | 0.60 | 0.80 | 42 | empty |
Compared structures
- 1MC0 · Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the… · the same entry in another collection · chain A against A, TM-score 1.00
- Q922S4 · AlphaFold monomer V2.0 prediction for cgmp-dependent 3',5'-cyclic phosphodiesterase… · a predicted model of the same protein · chain A against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q922S4
- Elsewhere: RCSB PDB 1MC0 · PDBe 1MC0 · UniProt Q922S4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.