MolNFT v2 · #14532 · protein

Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains

1MC0: “Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B…”. X-ray diffraction at 2.86, 1 ligand (PCG), 2 pockets (best druggability 0.77). MolNFT v2 #14532 on GenesisL1: 3D structure…

PDB: 1MC0
Type: protein
Length: 341 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.86
Source: Mus musculus
Molecule: 3',5'-cyclic nucleotide phosphodiesterase 2A
EC: 3.1.4.35
UniProt: Q922S4
Ligands: PCG
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · resolution 2.86 · 1 distinct chain · 44% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3',5'-cyclic nucleotide phosphodiesterase 2A (EC 3.1.4.35)	protein	341	44% helix, 25% strand	Q922S4

Ligands and binding sites

PCG · Cyclic guanosine monophosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.77	0.95	23	PCG
2	232	0.60	0.80	42	empty

Compared structures

1MC0 · Regulatory segment of mouse 3',5'-cyclic nucleotide phosphodiesterase 2A, containing the… · the same entry in another collection · chain A against A, TM-score 1.00
Q922S4 · AlphaFold monomer V2.0 prediction for cgmp-dependent 3',5'-cyclic phosphodiesterase… · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q922S4
Elsewhere: RCSB PDB 1MC0 · PDBe 1MC0 · UniProt Q922S4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.