Research workbench
Crystal structure of SOCS1 in complex with elonginb and elonginc
Analyse Crystal structure of SOCS1 in complex with elonginb and elonginc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6C5X
- Type
- protein
- Length
- 665 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongin-B; Elongin-C; Suppressor of cytokine signalling 1; GP130 peptide fragment
- UniProt
- Q15370, Q15369, C0LEJ4
- Pockets
- 7 · best druggability 0.61
Structure
x-ray diffraction · 7 distinct chains · 32% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Elongin-B | protein | 100 | 15% helix, 40% strand | Q15370 |
| C | Elongin-C | protein | 83 | 48% helix, 16% strand | Q15369 |
| E | Elongin-B | protein | 104 | 14% helix, 37% strand | Q15370 |
| F | Elongin-C | protein | 81 | 49% helix, 16% strand | Q15369 |
| D | Suppressor of cytokine signalling 1 | protein | 141 | 32% helix, 23% strand | C0LEJ4 |
| A | Suppressor of cytokine signalling 1 | protein | 151 | 38% helix, 21% strand | C0LEJ4 |
| G | GP130 peptide fragment | protein | 5 | 0% helix, 20% strand | — |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 449 | 0.61 | 0.75 | 51 | empty |
| 2 | 267 | 0.57 | 0.77 | 27 | empty |
| 3 | 177 | 0.51 | 0.78 | 26 | empty |
| 4 | 74 | 0.45 | 0.81 | 16 | empty |
| 5 | 87 | 0.39 | 0.77 | 26 | empty |
Interfaces
10 interfaces between chains.
- B–C · 1092 Ų buried · 12 hydrogen bonds · protein-protein
- E–F · 1082 Ų buried · 11 hydrogen bonds · protein-protein
- C–A · 877 Ų buried · 3 hydrogen bonds · protein-protein
- F–D · 846 Ų buried · 2 hydrogen bonds · protein-protein
- A–G · 405 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 6C5X · Crystal Structure of SOCS1 in complex with ElonginB and ElonginC · the same entry in another collection · chain G against G, TM-score 1.00
- Q15370 · AlphaFold monomer V2.0 prediction for elongin-B (Q15370) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q15369 · AlphaFold monomer V2.0 prediction for elongin-C (Q15369) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15370
- Every structure of UniProt Q15369
- Every structure of UniProt C0LEJ4
- Elsewhere: RCSB PDB 6C5X · PDBe 6C5X · UniProt Q15370 · UniProt Q15369 · UniProt C0LEJ4
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