Research workbench
Actinin-1 ef-hand bound to the CAV1.2 iq motif
Analyse Actinin-1 ef-hand bound to the CAV1.2 iq motif in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6C0A
- Type
- protein
- Length
- 94 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-actinin-1; Voltage-dependent L-type calcium channel subunit alpha-1C
- UniProt
- Q7TPR4, Q13936
- Pockets
- 1 · best druggability 0.61
Structure
solution nmr · 2 distinct chains · 62% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-actinin-1 | protein | 71 | 52% helix, 10% strand | Q7TPR4 |
| B | Voltage-dependent L-type calcium channel subunit alpha-1C | protein | 23 | 91% helix, 0% strand | Q13936 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.61 | 0.90 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 742 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6C0A · Actinin-1 EF-Hand bound to the Cav1.2 IQ Motif · the same entry in another collection · chain A against A, TM-score 1.00
- Q7TPR4 · AlphaFold monomer V2.0 prediction for alpha-actinin-1 (Q7TPR4) · a predicted model of the same protein · chain A against A, TM-score 0.75
- Q13936 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7TPR4
- Every structure of UniProt Q13936
- Elsewhere: RCSB PDB 6C0A · PDBe 6C0A · UniProt Q7TPR4 · UniProt Q13936
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