Research workbench
Crystal structure of WDR5-MB(S4) monobody complex
Analyse Crystal structure of WDR5-MB(S4) monobody complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BYN
- Type
- protein
- Length
- 401 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing protein 5; WDR5-binding monobody, MB(S4)
- UniProt
- P61964
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| W | Wd repeat-containing protein 5 | protein | 305 | 0% helix, 52% strand | P61964 |
| M | WDR5-binding monobody, MB(S4) | protein | 96 | 0% helix, 54% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 494 | 0.73 | 0.82 | 45 | empty |
| 2 | 89 | 0.33 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- W–M · 725 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6BYN · Crystal structure of WDR5-Mb(S4) monobody complex · the same entry in another collection · chain W against W, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61964
- Elsewhere: RCSB PDB 6BYN · PDBe 6BYN · UniProt P61964
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