Research workbench

Crystal structure of phosphorylation-mimicking mutant T356D of annexin VI

Analyse Crystal structure of phosphorylation-mimicking mutant T356D of annexin VI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1M9I
Type: protein
Length: 664 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin VI
UniProt: P08133
Ligands: CA
Pockets: 12 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin VI	protein	664	69% helix, 0% strand	P08133

Ligands and binding sites

CA · Calcium ion · metal · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	828	0.81	0.84	62	empty
2	308	0.62	0.79	31	empty
3	159	0.58	0.83	19	empty
4	107	0.53	0.83	26	empty
5	105	0.52	0.83	21	empty

Compared structures

1M9I · Crystal Structure Of Phosphorylation-Mimicking Mutant T356D Of Annexin VI · the same entry in another collection · chain A against A, TM-score 1.00
P08133 · AlphaFold monomer V2.0 prediction for annexin A6 (P08133) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08133
Elsewhere: RCSB PDB 1M9I · PDBe 1M9I · UniProt P08133

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.