Research workbench
Structure of bare actin filament, backbone-averaged with sidechains truncated to alanine
Analyse Structure of bare actin filament, backbone-averaged with sidechains truncated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BNU
- Type
- protein
- Length
- 2,936 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle
- UniProt
- P68135
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Actin, alpha skeletal muscle | protein | 367 | 40% helix, 19% strand | P68135 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1030 | 0.81 | 0.82 | 126 | empty |
| 2 | 1103 | 0.81 | 0.82 | 131 | empty |
| 3 | 1053 | 0.81 | 0.82 | 129 | empty |
| 4 | 1184 | 0.81 | 0.82 | 152 | empty |
| 5 | 1071 | 0.81 | 0.82 | 135 | empty |
Interfaces
13 interfaces between chains.
- E–G · 369 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 368 Ų buried · 2 hydrogen bonds · protein-protein
- C–E · 364 Ų buried · 2 hydrogen bonds · protein-protein
- F–H · 362 Ų buried · 2 hydrogen bonds · protein-protein
- D–F · 357 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6BNU · Structure of bare actin filament, backbone-averaged with sidechains truncated to alanine · the same entry in another collection · chain E against E, TM-score 1.00
- P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68135
- Elsewhere: RCSB PDB 6BNU · PDBe 6BNU · UniProt P68135
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