Research workbench
Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc
Analyse Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BGI
- Type
- protein
- Length
- 1,020 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anoctamin-1
- UniProt
- Q8BHY3
- Ligands
- CA
- Pockets
- 12 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 66% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Anoctamin-1 | protein | 510 | 66% helix, 0% strand | Q8BHY3 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1180 | 0.84 | 0.85 | 117 | empty |
| 2 | 778 | 0.83 | 0.85 | 88 | CA |
| 3 | 658 | 0.82 | 0.87 | 67 | empty |
| 4 | 798 | 0.77 | 0.81 | 70 | empty |
| 5 | 459 | 0.65 | 0.78 | 51 | empty |
Interfaces
1 interface between chains.
- A–B · 586 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6BGI · Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc · the same entry in another collection · chain A against A, TM-score 1.00
- Q8BHY3 · AlphaFold monomer V2.0 prediction for anoctamin-1 (Q8BHY3) · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BHY3
- Elsewhere: RCSB PDB 6BGI · PDBe 6BGI · UniProt Q8BHY3
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