Research workbench
Cryo-EM structure of TRPM4 in ATP bound state with long coiled coil at 3.3 ångström resolution
Analyse Cryo-EM structure of TRPM4 in ATP bound state with long coiled coil at 3.3… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BCQ
- Type
- protein
- Length
- 3,932 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily M member 4
- UniProt
- Q7TN37
- Ligands
- ATP
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 60% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, C, D | Transient receptor potential cation channel subfamily M member 4 | protein | 983 | 60% helix, 7% strand | Q7TN37 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 4 copies · chains B, D, A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1141 | 0.86 | 0.86 | 99 | empty |
| 2 | 1039 | 0.77 | 0.79 | 87 | empty |
| 3 | 993 | 0.76 | 0.79 | 75 | empty |
| 4 | 1070 | 0.76 | 0.79 | 89 | empty |
| 5 | 1133 | 0.76 | 0.79 | 88 | empty |
Interfaces
6 interfaces between chains.
- A–C · 3545 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 3540 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 3537 Ų buried · 10 hydrogen bonds · protein-protein
- B–A · 3525 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 34 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6BCQ · cryo-EM structure of TRPM4 in ATP bound state with long coiled coil at 3.3 angstrom… · the same entry in another collection · chain B against B, TM-score 1.00
- Q7TN37 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7TN37
- Elsewhere: RCSB PDB 6BCQ · PDBe 6BCQ · UniProt Q7TN37
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.