Research workbench
Crystal structure of UHRF1 ttd domain in complex with the polybasic region
Analyse Crystal structure of UHRF1 ttd domain in complex with the polybasic region in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6B9M
- Type
- protein
- Length
- 465 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase UHRF1
- EC
- 2.3.2.27
- UniProt
- E7EZF3, Q96T88
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) | protein | 150 | 6% helix, 46% strand | E7EZF3 |
| B | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) | protein | 148 | 6% helix, 47% strand | E7EZF3 |
| C | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) | protein | 150 | 6% helix, 44% strand | E7EZF3 |
| D | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) | protein | 17 | 0% helix, 0% strand | Q96T88 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 178 | 0.56 | 0.81 | 32 | empty |
| 2 | 166 | 0.46 | 0.75 | 32 | empty |
| 3 | 76 | 0.41 | 0.79 | 16 | empty |
| 4 | 53 | 0.24 | 0.72 | 12 | empty |
Interfaces
4 interfaces between chains.
- A–D · 814 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 471 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 377 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 229 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6B9M · Crystal structure of UHRF1 TTD domain in complex with the polybasic region · the same entry in another collection · chain A against A, TM-score 1.00
- E7EZF3 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase UHRF1 (E7EZF3) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E7EZF3
- Every structure of UniProt Q96T88
- Elsewhere: RCSB PDB 6B9M · PDBe 6B9M · UniProt E7EZF3 · UniProt Q96T88
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