UniProt Q96T88
E3 ubiquitin-protein ligase UHRF1 (Q96T88)
E3 ubiquitin-protein ligase UHRF1 (UniProt Q96T88), EC 2.3.2.27: 65 experimental structures on GenesisL1, 8 ligands bound, 13 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q96T88
- Protein
- E3 ubiquitin-protein ligase UHRF1
- EC
- 2.3.2.27
- Experimental structures
- 65
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 13 · 2 records with a druggable one
Structures
65 records of Q96T88 in the MolNFT archive: 65 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FAZ | Ubiquitin-Like Domain of Human Nuclear Zinc Finger Protein NP95 | x-ray diffraction | A, B | — | — |
| 2FAZ | Ubiquitin-like domain of human nuclear zinc finger protein NP95 | x-ray diffraction | A, B | — | — |
| 2L3R | NMR structure of UHRF1 Tandem Tudor Domains in a complex with Histone H3 peptide | solution nmr | A | — | — |
| 2L3R | NMR structure of UHRF1 tandem tudor domains in a complex with histone H3 peptide | solution nmr | A | — | — |
| 2LGG | Structure of PHD domain of UHRF1 in complex with H3 peptide | solution nmr | A | — | — |
| 2LGG | Structure of phd domain of UHRF1 in complex with H3 peptide | solution nmr | A | — | — |
| 2LGK | NMR Structure of UHRF1 PHD domains in a complex with histone H3 peptide | solution nmr | A | — | — |
| 2LGK | NMR structure of UHRF1 phd domains in a complex with histone H3 peptide | solution nmr | A | — | — |
| 2LGL | NMR structure of the UHRF1 PHD domain | solution nmr | A | — | — |
| 2LGL | NMR structure of the UHRF1 phd domain | solution nmr | A | — | — |
| 2PB7 | Crystal Structure of the SRA domain of the human UHRF1 protein | x-ray diffraction | A | — | — |
| 2PB7 | Crystal structure of the sra domain of the human UHRF1 protein | x-ray diffraction | A | — | — |
| 3ASK | Structure of UHRF1 in complex with histone tail | x-ray diffraction | A, B, C, D | — | — |
| 3ASK | Structure of UHRF1 in complex with histone tail | x-ray diffraction | A, B, C, D | — | — |
| 3ASL | Structure of UHRF1 in complex with histone tail | x-ray diffraction | A | — | — |
| 3ASL | Structure of UHRF1 in complex with histone tail | x-ray diffraction | A | — | — |
| 3BI7 | Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF1 | x-ray diffraction | A | — | — |
| 3BI7 | Crystal structure of the sra domain of E3 ubiquitin-protein ligase UHRF1 | x-ray diffraction | A | — | — |
| 3CLZ | The set and ring associated (SRA) domain of UHRF1 bound to methylated DNA | x-ray diffraction | A, B, C, D | — | — |
| 3CLZ | The set and ring associated (sra) domain of UHRF1 bound to methylated DNA | x-ray diffraction | A, B, C, D | — | — |
| 3DB3 | Crystal structure of the tandem tudor domains of the E3 ubiquitin-protein ligase UHRF1 in complex… | x-ray diffraction | A | — | — |
| 3DB3 | Crystal structure of the tandem tudor domains of the E3 ubiquitin- protein ligase UHRF1 in complex… | x-ray diffraction | A | — | — |
| 3DB4 | Crystal structure of the tandem tudor domains of the E3 ubiquitin-protein ligase UHRF1 | x-ray diffraction | A | — | — |
| 3DB4 | Crystal structure of the tandem tudor domains of the E3 ubiquitin- protein ligase UHRF1 | x-ray diffraction | A | — | — |
| 3DWH | Structural and Functional Analysis of SRA domain | x-ray diffraction | A | — | — |
| 3DWH | Structural and functional analysis of sra domain | x-ray diffraction | A | — | — |
| 3FL2 | Crystal structure of the ring domain of the E3 ubiquitin-protein ligase UHRF1 | x-ray diffraction | A | — | — |
| 3FL2 | Crystal structure of the ring domain of the E3 ubiquitin-protein ligase UHRF1 | x-ray diffraction | A | — | — |
| 3SHB | Crystal Structure of PHD Domain of UHRF1 | x-ray diffraction | A | — | — |
| 3SHB | Crystal structure of phd domain of UHRF1 | x-ray diffraction | A | — | — |
| 3SOU | Structure of UHRF1 PHD finger in complex with histone H3 1-9 peptide | x-ray diffraction | A, B | — | — |
| 3SOU | Structure of UHRF1 phd finger in complex with histone H3 1-9 peptide | x-ray diffraction | A, B | — | — |
| 3SOW | Structure of UHRF1 PHD finger in complex with histone H3K4me3 1-9 peptide | x-ray diffraction | A, B | — | — |
| 3SOW | Structure of UHRF1 phd finger in complex with histone H3K4ME3 1-9 peptide | x-ray diffraction | A, B | — | — |
| 3SOX | Structure of UHRF1 PHD finger in the free form | x-ray diffraction | A, B | — | — |
| 3SOX | Structure of UHRF1 phd finger in the free form | x-ray diffraction | A, B | — | — |
| 3T6R | Structure of UHRF1 in complex with unmodified H3 N-terminal tail | x-ray diffraction | A, B | — | — |
| 3T6R | Structure of UHRF1 in complex with unmodified H3 N-terminal tail | x-ray diffraction | A, B | — | — |
| 3ZVY | PHD finger of human UHRF1 in complex with unmodified histone H3 N- terminal tail | x-ray diffraction | A, B | — | — |
| 3ZVY | Phd finger of human UHRF1 in complex with unmodified histone H3 N- terminal tail | x-ray diffraction | A, B | — | — |
| 3ZVZ | PHD finger of human UHRF1 | x-ray diffraction | B | — | — |
| 3ZVZ | Phd finger of human UHRF1 | x-ray diffraction | B | — | — |
| 4GY5 | Crystal structure of the tandem tudor domain and plant homeodomain of UHRF1 with Histone H3K9me3 | x-ray diffraction | A, B, C, D | — | — |
| 4GY5 | Crystal structure of the tandem tudor domain and plant homeodomain of UHRF1 with histone H3K9ME3 | x-ray diffraction | A, B, C, D | — | — |
| 4QQD | Crystal Structure of tandem tudor domains of UHRF1 in complex with a small organic molecule | x-ray diffraction | A, B | — | — |
| 4QQD | Crystal structure of tandem tudor domains of UHRF1 in complex with a small organic molecule | x-ray diffraction | A, B | — | — |
| 5C6D | Crystal structure of USP7 in complex with UHRF1 | x-ray diffraction | C, D | — | — |
| 5IAY | NMR structure of UHRF1 tandem tudor domains in a complex with spacer peptide | solution nmr | A | — | — |
| 5XPI | Structure of UHRF1 ttd in complex with NV01 | x-ray diffraction | A | 8C3 | — |
| 5YY9 | Crystal structure of tandem tudor domain of human UHRF1 in complex with LIG1-K126ME3 | x-ray diffraction | A, B | — | — |
| 5YYA | Crystal structure of tandem tudor domain of human UHRF1 | x-ray diffraction | A | SO4 | — |
| 6B9M | Crystal structure of UHRF1 TTD domain in complex with the polybasic region | x-ray diffraction | D | — | 3 (best 0.46) |
| 6B9M | Crystal structure of UHRF1 ttd domain in complex with the polybasic region | x-ray diffraction | D | — | — |
| 6IIW | Crystal structure of human UHRF1 phd finger in complex with PAF15 | x-ray diffraction | A | ZN | — |
| 6VCS | SRA domain of UHRF1 in complex with DNA | x-ray diffraction | A, B, E | UNX | 7 (best 0.76) |
| 6VCS | Sra domain of UHRF1 in complex with DNA | x-ray diffraction | A, B, E | UNX | — |
| 6VED | Solution structure of the TTD and linker region of UHRF1 | solution nmr | A | — | — |
| 6VED | Solution structure of the ttd and linker region of UHRF1 | solution nmr | A | — | — |
| 6VYJ | Human UHRF1 ttd domain in complex with a fragment | x-ray diffraction | A | RVV, BGC | — |
| 6W92 | Human UHRF1 TTD domain | x-ray diffraction | A | — | — |
5 records more on the page itself.
Ligands
- ZN · Zinc ion · in 3 records
- SO4 · Sulfate ion · in 2 records
- UNX · Unknown atom or ion · in 2 records
- 8C3 · N-[3-(diethylamino)propyl]-2-(12-methyl-9-oxidanylidene-5-thia-1,10,11-triazatricyclo[6.4.0.0^2, 6]dodeca-2(6),3,7,11-tetraen-10-yl)ethanamide · in 1 record
- 8NF · 5-amino-2,4-dimethylpyridine · in 1 record
- BGC · beta-D-glucopyranose · in 1 record
- RVV · 2,4-dimethylpyridine · in 1 record
- SCN · Thiocyanate ion · in 1 record
Elsewhere
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