Research workbench
Structure of the mechanosensitive channel PIEZO1
Analyse Structure of the mechanosensitive channel PIEZO1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6B3R
- Type
- protein
- Length
- 4,554 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Piezo-type mechanosensitive ion channel component 1; Piezo-type mechanosensitive ion…
- UniProt
- E2JF22
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 56% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Piezo-type mechanosensitive ion channel component 1 | protein | 1502 | 56% helix, 4% strand | E2JF22 |
| B, D, F | Piezo-type mechanosensitive ion channel component 1, unknown fragment | protein | 16 | 0% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 236 | 0.82 | 0.94 | 32 | empty |
| 2 | 1161 | 0.81 | 0.82 | 83 | empty |
| 3 | 1182 | 0.81 | 0.82 | 87 | empty |
| 4 | 1193 | 0.80 | 0.81 | 85 | empty |
| 5 | 578 | 0.78 | 0.85 | 100 | empty |
Interfaces
9 interfaces between chains.
- C–E · 3322 Ų buried · 36 hydrogen bonds · protein-protein
- A–C · 3287 Ų buried · 34 hydrogen bonds · protein-protein
- A–E · 3238 Ų buried · 30 hydrogen bonds · protein-protein
- E–F · 499 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 492 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6B3R · Structure of the mechanosensitive channel Piezo1 · the same entry in another collection · chain C against C, TM-score 1.00
- E2JF22 · AlphaFold monomer V2.0 prediction for piezo-type mechanosensitive ion channel component 1… · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E2JF22
- Elsewhere: RCSB PDB 6B3R · PDBe 6B3R · UniProt E2JF22
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