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Crystal structure of non-canonical dimeric guanylyl cyclase domain of rhogc fusion protein from the aquatic fungus blastocladiella emersonii
Analyse Crystal structure of non-canonical dimeric guanylyl cyclase domain of rhogc… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6AOB
- Type
- protein
- Length
- 358 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bacterio-RHODOPSIN/GUANYLYL cyclase 1 fusion protein
- UniProt
- A0A060H1D7
- Ligands
- MN
- Pockets
- 4 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bacterio-RHODOPSIN/GUANYLYL cyclase 1 fusion protein | protein | 180 | 36% helix, 32% strand | A0A060H1D7 |
| B | Bacterio-RHODOPSIN/GUANYLYL cyclase 1 fusion protein | protein | 178 | 36% helix, 34% strand | A0A060H1D7 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 2 copies · chains A, B
- TLA · L(+)-tartaric acid · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 260 | 0.83 | 0.95 | 43 | empty |
| 2 | 164 | 0.51 | 0.79 | 35 | empty |
| 3 | 129 | 0.45 | 0.77 | 17 | empty |
| 4 | 63 | 0.31 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1334 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6AOB · Crystal structure of non-canonical dimeric guanylyl cyclase domain of RhoGC fusion… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A060H1D7
- Elsewhere: RCSB PDB 6AOB · PDBe 6AOB · UniProt A0A060H1D7
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