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Synaptotagmin-7, C2A- and C2B-domains

Analyse Synaptotagmin-7, C2A- and C2B-domains in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ANK
Type: protein
Length: 525 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Synaptotagmin-7
UniProt: Q62747
Ligands: CA
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Synaptotagmin-7	protein	262	10% helix, 52% strand	Q62747
B	Synaptotagmin-7	protein	263	10% helix, 51% strand	Q62747

Ligands and binding sites

CA · Calcium ion · metal · 8 copies · chains A, B
EDO · 1,2-ethanediol · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	94	0.32	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 522 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

6ANK · Synaptotagmin-7, C2A- and C2B-domains · the same entry in another collection · chain A against A, TM-score 1.00
Q62747 · AlphaFold monomer V2.0 prediction for synaptotagmin-7 (Q62747) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62747
Elsewhere: RCSB PDB 6ANK · PDBe 6ANK · UniProt Q62747

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