Research workbench
Calcium release-activated calcium channel protein 1, P288L mutant
Analyse Calcium release-activated calcium channel protein 1, P288L mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6AKI
- Type
- protein
- Length
- 1,800 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium release-activated calcium channel protein 1
- UniProt
- Q9U6B8
- Ligands
- CL
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, O, P, Q, R, S, T | Calcium release-activated calcium channel protein 1 | protein | 150 | 83% helix, 0% strand | Q9U6B8 |
Ligands and binding sites
- CL · Chloride ion · ion · 4 copies · chains A, B, C, D, E, F, O, P, Q, R, S, T
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 837 | 0.86 | 0.88 | 108 | CL |
| 2 | 843 | 0.83 | 0.85 | 100 | empty |
| 3 | 1001 | 0.78 | 0.80 | 108 | empty |
| 4 | 771 | 0.78 | 0.82 | 111 | CL |
| 5 | 576 | 0.69 | 0.78 | 53 | empty |
Interfaces
31 interfaces between chains.
- A–E · 1647 Ų buried · 1 hydrogen bond · protein-protein
- R–S · 1622 Ų buried · 1 hydrogen bond · protein-protein
- Q–R · 1617 Ų buried · 0 hydrogen bonds · protein-protein
- P–Q · 1561 Ų buried · 1 hydrogen bond · protein-protein
- S–T · 1560 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6AKI · Calcium release-activated calcium channel protein 1, P288L mutant · the same entry in another collection · chain T against T, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9U6B8
- Elsewhere: RCSB PDB 6AKI · PDBe 6AKI · UniProt Q9U6B8
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