Research workbench
Crystal structure of M120A mutant of O-acetylserine sulfhydrylase from haemophilus influenzae in complex with high affinity inhibitory peptide from serine acetyl transferase of salmonella typhimurium
Analyse Crystal structure of M120A mutant of O-acetylserine sulfhydrylase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6AIF
- Type
- protein
- Length
- 318 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine synthase; Peptide from serine acetyltransferase
- EC
- 2.5.1.47
- UniProt
- P45040, P29847
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine synthase (EC 2.5.1.47) | protein | 310 | 41% helix, 18% strand | P45040 |
| B | Peptide from serine acetyltransferase | protein | 8 | 0% helix, 13% strand | P29847 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 115 | 0.51 | 0.81 | 24 | empty |
| 2 | 80 | 0.39 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 592 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (cofactor).
Compared structures
- 6AIF · Crystal structure of M120A mutant of O-acetylserine sulfhydrylase from Haemophilus… · the same entry in another collection · chain A against A, TM-score 1.00
- P45040 · AlphaFold monomer V2.0 prediction for cysteine synthase (P45040) · a predicted model of the same protein · chain A against A, TM-score 1.00
- P29847 · AlphaFold monomer V2.0 prediction for serine acetyltransferase (P29847) · a predicted model of the same protein · chain B against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45040
- Every structure of UniProt P29847
- Elsewhere: RCSB PDB 6AIF · PDBe 6AIF · UniProt P45040 · UniProt P29847
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