UniProt P45040
Cysteine synthase (P45040)
Cysteine synthase (UniProt P45040), EC 2.5.1.47: 40 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P45040
- Protein
- Cysteine synthase
- EC
- 2.5.1.47
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 9 · 6 records with a druggable one
Structures
41 records of P45040 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Y7L | O-Acetylserine Sulfhydrylase Complex | x-ray diffraction | A | — | — |
| 1Y7L | O-acetylserine sulfhydrylase complex | x-ray diffraction | A | — | — |
| 3IQG | Structure of O-Acetylserine Sulfhydrylase in Complex with Peptide MNWNI | x-ray diffraction | X | — | — |
| 3IQG | Structure of O-acetylserine sulfhydrylase in complex with peptide mnwni | x-ray diffraction | X | — | — |
| 3IQH | Structure of O-Acetylserine Sulfhydrylase in Complex with Peptide MNYDI | x-ray diffraction | X | — | — |
| 3IQH | Structure of O-acetylserine sulfhydrylase in complex with peptide mnydi | x-ray diffraction | X | — | — |
| 3IQI | Structure of O-Acetylserine Sulfhydrylase in Complex with Peptide MNENI | x-ray diffraction | X | — | — |
| 3IQI | Structure of O-acetylserine sulfhydrylase in complex with peptide mneni | x-ray diffraction | X | — | — |
| 4HO1 | The Crystal structure of Haemophilus influenzae O-acetylserine sulfhydrylase at 1.85A resolution | x-ray diffraction | X | — | — |
| 4HO1 | The crystal structure of haemophilus influenzae O-acetylserine sulfhydrylase at 1.85A resolution | x-ray diffraction | X | — | — |
| 4LI3 | Crystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus influenzae in complex with high… | x-ray diffraction | X | — | — |
| 4LI3 | Crystal structure of O-acetylserine sulfhydrylase from haemophilus influenzae in complex with high… | x-ray diffraction | X | — | — |
| 4NU8 | Crystal structure of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high… | x-ray diffraction | X | — | — |
| 4NU8 | Crystal structure of O-acetylserine sulfhydrylase from haemophilus influenzae in complex with high… | x-ray diffraction | X | — | — |
| 4ORE | Cyrstal structure of O-acetylserine sulfhydrylase ternary complex from Haemophilus influenzae at… | x-ray diffraction | X | — | — |
| 4ORE | Cyrstal structure of O-acetylserine sulfhydrylase ternary complex from haemophilus influenzae at… | x-ray diffraction | X | — | — |
| 4ZU1 | Crystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus influenzae in complex with… | x-ray diffraction | X | OAS | 1 (best 0.42) |
| 4ZU1 | Crystal structure of O-acetylserine sulfhydrylase from haemophilus influenzae in complex with… | x-ray diffraction | X | — | — |
| 4ZU6 | Crystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus influenzae in complex with… | x-ray diffraction | X | — | — |
| 4ZU6 | Crystal structure of O-acetylserine sulfhydrylase from haemophilus influenzae in complex with… | x-ray diffraction | X | — | — |
| 5DBE | Crystal structure of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with… | x-ray diffraction | X | — | — |
| 5DBE | Crystal structure of O-acetylserine sulfhydrylase from haemophilus influenzae in complex with… | x-ray diffraction | X | — | — |
| 5DBH | Crystal structure of O-acetylserine sulfhydrylase from haemophilus influenzae in complex with… | x-ray diffraction | X | — | — |
| 5DBH | Crystal structure of O-acetylserine sulfhydrylase from haemophilus influenzae in complex with… | x-ray diffraction | X | — | — |
| 5XCN | Crystal structure of M120A mutant of O-acetyl-L-serine sulfahydrylase from Haemophilus influenzae | x-ray diffraction | X | — | 1 (best 0.61) |
| 5XCN | Crystal structure of M120A mutant of O-acetyl-L-serine sulfahydrylase from haemophilus influenzae | x-ray diffraction | X | — | — |
| 5XCP | Crystal structure of M92A mutant of O-acetyl-L-serine sulfhydrylase from haemophilus influenzae | x-ray diffraction | X | — | — |
| 5XCW | Crystal structure of M92A-M120A double mutant of O-acetyl-L-serine sulfhydrylase from haemophilus… | x-ray diffraction | X | — | — |
| 6AIF | Crystal structure of M120A mutant of O-acetylserine sulfhydrylase from haemophilus influenzae in… | x-ray diffraction | A | — | — |
| 7C35 | Crystal structure of M96A mutant of O-acetyl-L-serine sulfhydrylase from haemophilus influenzae | x-ray diffraction | A | — | — |
| 7CM8 | High resolution crystal structure of M92A mutant of O-acetyl-L-serine sulfhydrylase from… | — | — | — | |
| 7DJQ | Crystal structure of O-acetyl L-serine sulfhydrylase from haemophilus influenzae in complex with… | x-ray diffraction | B, A | NA | — |
| 7EWO | Crystal Structure of D67A, E68P double mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus… | x-ray diffraction | A | — | — |
| 7EWO | Crystal structure of D67A, E68P double mutant of O-acetyl-L-serine sulfhydrylase from haemophilus… | x-ray diffraction | A | — | — |
| 7YOE | Crystal Structure of A68P single mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus… | x-ray diffraction | A | — | 1 (best 0.68) |
| 7YOF | Crystal Structure of Triple mutant (D67E, A68P, I88L) of O-acetyl-L-serine sulfhydrylase from… | x-ray diffraction | A | — | 1 (best 0.64) |
| 7YOG | Crystal Structure of I88L single mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus… | x-ray diffraction | A | — | 1 (best 0.62) |
| 7YOI | Crystal structure of I88L single mutant of O-acetylserine sulfhydrylase from Haemophilus influenzae… | x-ray diffraction | A | — | 2 (best 0.44) |
| 7YOL | Crystal structure of tetra mutant (D67E, A68P, L98I, A301S) of O-acetylserine sulfhydrylase from… | x-ray diffraction | A | — | 1 (best 0.58) |
| 8GSK | Crystal Structure of S302G single mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus… | x-ray diffraction | A | — | 1 (best 0.67) |
| P45040 | AlphaFold monomer V2.0 prediction for cysteine synthase (P45040) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4LI3 chain X against the predicted model P45040: TM-score 1.00, RMSD 0.26 Å
- 4LI3 chain X against the predicted model P45040: TM-score 1.00, RMSD 0.26 Å
- 4HO1 chain X against the predicted model P45040: TM-score 1.00, RMSD 0.27 Å
- 4HO1 chain X against the predicted model P45040: TM-score 1.00, RMSD 0.27 Å
- 4NU8 chain X against the predicted model P45040: TM-score 1.00, RMSD 0.28 Å
- 4NU8 chain X against the predicted model P45040: TM-score 1.00, RMSD 0.28 Å
- 6AIF chain A against the predicted model P45040: TM-score 1.00, RMSD 0.32 Å
- 7YOI chain A against the predicted model P45040: TM-score 1.00, RMSD 0.32 Å
- 7YOL chain A against the predicted model P45040: TM-score 1.00, RMSD 0.35 Å
- 5XCW chain X against the predicted model P45040: TM-score 1.00, RMSD 0.37 Å
Elsewhere
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