Research workbench
Structure of the human PKD1/PKD2 complex
Analyse Structure of the human PKD1/PKD2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6A70
- Type
- protein
- Length
- 2,086 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polycystin-2; Polycystin-1
- UniProt
- Q13563, P98161
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 4 distinct chains · 45% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polycystin-2 | protein | 448 | 41% helix, 6% strand | Q13563 |
| B | Polycystin-1 | protein | 704 | 39% helix, 6% strand | P98161 |
| F | Polycystin-2 | protein | 463 | 51% helix, 10% strand | Q13563 |
| G | Polycystin-2 | protein | 471 | 52% helix, 10% strand | Q13563 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 845 | 0.85 | 0.87 | 98 | empty |
| 2 | 534 | 0.82 | 0.88 | 65 | empty |
| 3 | 928 | 0.81 | 0.83 | 138 | empty |
| 4 | 788 | 0.80 | 0.83 | 99 | empty |
| 5 | 950 | 0.79 | 0.81 | 85 | empty |
Interfaces
6 interfaces between chains.
- F–G · 3360 Ų buried · 18 hydrogen bonds · protein-protein
- B–G · 2951 Ų buried · 14 hydrogen bonds · protein-protein
- A–F · 2901 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 890 Ų buried · 0 hydrogen bonds · protein-protein
- B–F · 65 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13563
- Every structure of UniProt P98161
- Elsewhere: RCSB PDB 6A70 · PDBe 6A70 · UniProt Q13563 · UniProt P98161
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